Barely Significant
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SpiR is a gut microbial enzyme that drives cholesterol conversion.

Nat Commun · 2026 · PMC13079761 · PMID 41980965

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marginally significantp = 0.05actually significant
coli lysates expressing IsmA and SpiR revealed that SpiR generated a higher cholestenone signal, with a marginally significant difference ( U = 9.0, p = 0.05, Mann–Whitney U test).

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