A bioactive magnesium alloy scaffold integrated with BMSCs-Loaded 3D microspheres synergistically promotes femoral head osteonecrosis repair by improving the osteogenic-angiogenic microenvironment.

Functional enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was conducted for the identified differentially expressed genes using the R package clusterProfiler, with enriched pathways defined by adjusted P values < 0.05 (significant) or < 0.01 (highly significant) [ 74 ]. 4.4.3 Western blot analysis of osteoblasts in transwell co-culture system To validate the transcriptomic alterations identified in the Transwell co-culture system at the protein level, Western blot analysis was performed on osteoblasts harvested from the lower chamber at day 7.

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