Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity.

Blood biochemistry analyses ( Table S1 ) showed no signs of hepatic or or renal toxicity, with even a slight trend toward lower transaminase levels in HFD-fed mice injected with EV CTL compared to Vehicle group, supporting the absence of toxicity and confirming the good tolerance of repeated EV injections.

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