Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.

Among women, all sex hormones showed significant genetic correlation with serum urate (ToT: r g = 0.092, [95% CI: 0.034, 0.150], and p = 0.002; BioT: r g = −0.076, [95% CI: −0.129, −0.022], and p = 0.006; SHBG: r g = −0.226, [95% CI: −0.294, −0.157], and p = 8.76 × 10 −11 ; age at menarche: r g = −0.131, [95% CI: −0.173, −0.089], and p = 8.15 × 10 −10 ; and age at menopause: r g = −0.076, [95% CI: −0.128, −0.023], and p = 0.005), expect that estradiol showed marginally significant correlation with serum urate ( r g = −0.248, [95% CI: −0.442, −0.054], and p = 0.012).

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