Tracking early cognitive decline in preclinical AD with brain MRI similarity.

Alzheimers Dement · 2026 · PMC13093512 · PMID 41851031

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failed to reach significanceno p-value reported

15 , 66 In the elevated Aβ‐positive group, brain similarity remained the strongest predictor across most cognitive domains, with consistent associations across both cohorts for PACC, ADL, executive function, and memory, even when conventional markers failed to reach significance.

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