Late-life methionine restriction attenuates neuroinflammation in Alzheimer's disease mice via FGF21 activation in a metabolism-independent manner.

Alzheimers Dement · 2026 · PMC13093841 · PMID 41830497

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hedged sentence

0.0576

closest p · 1.2× alpha

0.0576

boldest claim

The sentences

marginally significantp = 0.0576so close (0.05 < p ≤ 0.1)

Furthermore, MR significantly upregulated the mRNA expression of Psd‐95 ( p < 0.01) and Bdnf ( p < 0.05) in AD+Sh‐NC mice compared with those fed ND, but brain FGFR1 knockdown offset these beneficial effects, with Psd‐95 showing a marginally significant decrease ( p = 0.0576) and Bdnf showing a significant reduction ( p < 0.05) (Figure 6J ; Figure S5B ).

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