Cyclic nucleotide phosphodiesterases as drug targets.

Pharmacol Rev · 2025 · PMC13095499 · PMID 40081105

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may be significantno p-value reported

The implications of these gene expression changes may be significant because SABAs and LABAs, which are consumed by individuals with asthma and COPD on a long-term basis, could attenuate signaling mediated by all GPCRs that stimulate adenylyl cyclase ( Giembycz, 1996 ).

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