Integrated Bioinformatic Identification and Experimental Validation Reveal That Aging Exacerbates ARDS Through MAPK14/ADM/MAPK8 Axis.

Furthermore, correlation analysis with established ARDS-related regulatory genes from GeneCards revealed highly significant associations: MAPK14 expression was strongly positively correlated with CEBPA ( r = 0.86), a transcription factor critical in inflammation, while MAPK8 was strongly negatively correlated with IL-10 ( r = −0.63), a key anti-inflammatory cytokine ( Figure 6A and B ).

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