Pre-treatment lysis time of plasma-derived fibrin clots and bleeding in patients on oral anticoagulants for atrial fibrillation in the ARISTOTLE trial.

Furthermore, within lysis time Q4 (2940 to 11 302 s), there was a numerical trend towards higher rates of cardiovascular events with increasing lysis time on adjusted analysis ( Figure 3 ) that was consistent with previous findings in ACS patients and warrants future scrutiny of those with very high lysis times.

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