Levels and instability of transthyretin and correlations with core biomarkers in Alzheimer's disease.

Sci Rep · 2026 · PMC13100035 · PMID 41820479

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hedged sentence

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

a trend toward significancep = 0.052so close (0.05 < p ≤ 0.1)

However, the CSF TTR × diagnosis interaction term reached significance for t-Tau ( p = 0.013), p-Tau181 ( p = 0.020), and NfL ( p = 0.006), and showed a trend toward significance for Aβ40 ( p = 0.052), indicating that the strength and direction of associations differ across diagnostic stages (Fig. 2 A-D).

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