Relating Cumulative Life's Essential 8 Score With Cardiovascular Disease and Death: The Framingham Heart Study.

JACC Adv · 2026 · PMC13101685 · PMID 41996786

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a decreasing trendno p-value reported

Nevertheless, we observed that most participants had a negative LE8 slope, reflecting a decreasing trend of the cumulative LE8 during the 25-year period, highlighting the importance of targeted interventions to improve CVH among all U.S. adults.

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highly significantno p-value reported

We observed a highly significant difference in survival time across quartile groups, with the highest quartile (Q4) showing the longest survival time free of disease or death, followed by Q3, Q2, and finally Q1, for all outcomes (all log-rank P values <0.0001).

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