Marine-derived extracts of <i>Peyssonnelia caulifera Okamura</i> and <i>Meristotheca papulosa</i> demonstrate differential efficacy in modulating obesity-related metabolic skewing revealed by integrative analysis of extract metabolomics and microbiome profiles.

Conversely, metabolites such as inosine, dalbergin, and certain unknown metabolites exhibited strong positive correlations with these parameters, which were also highly significant (p < 0.0001).

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Notably, mice in the HF + MPE group exhibited a significant reduction in weight gain compared with those in the HF group, whereas the HF + PCE group demonstrated a decreasing trend without statistical significance ( Figure 1B ).

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