highly significantP < 0.001
Differences between the groups were not significant at baseline (t = 1.265, P = 0.22) and 24 h (t = 1.962, P = 0.07), but became highly significant at 48 h (t = 5.885, P < 0.001), 72 h (U = 0, P < 0.001), and 96 h (t = 9.132, P < 0.001) (Fig. 8 A).