Proteomics of human duodenum in pre-diabetes and type 2 diabetes reveals potential novel therapeutic targets for aetiology and therapeutics.

Clin Proteomics · 2026 · PMC13104399 · PMID 41840478

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borderline significantno p-value reported

At the mRNA level only borderline significant changes in Chmp3 and Fubp3 were detected using the duodenum of the pre-clinical high-fat diet C57BL/6J mouse model of pre-diabetes.

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of borderline significanceno p-value reported

The decreased mRNA expression of Chmp3 and Fubp3 in mouse duodenum, presented a large effect size matching the direction of change observed in the orthologous human proteins, in spite of borderline significance.

also in 2,624 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.