It may be significant that infecting HSV genomes initially localize to the periphery of nuclear ND10 domains [ 31 - 33 ], and that ICP0 disrupts ND10 [ 34 - 36 ] by targeting several components, including PML, for destruction [ 37 - 39 ].
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It may be significant that infecting HSV genomes initially localize to the periphery of nuclear ND10 domains [ 31 - 33 ], and that ICP0 disrupts ND10 [ 34 - 36 ] by targeting several components, including PML, for destruction [ 37 - 39 ].