Integrated multi-omics identifies MCRS1 as a causal hub linking aging, metabolic syndrome, and breast cancer progression.

Int J Surg · 2026 · PMC13105736 · PMID 41556158

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of borderline significanceno p-value reported

Furthermore, we observed a strong positive enrichment trend for pathways related to DNA synthesis and metabolism, including “Regulation of DNA Replication” (NES = 2.64), “Glycine, Serine and Threonine Metabolism” (NES = 2.64), and “Carbon Metabolism” (NES = 2.92), although the adjusted P -values for these pathways were of borderline significance (Fig. 7 G–I).

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