GPR183 potentiates CAR-T cell infiltration and antitumor immunity through a positive feedback loop involving the oxysterol 7α,25-OHC.

Mol Cancer · 2026 · PMC13107666 · PMID 41840629

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an increasing trendno p-value reported

Although the expression of PD-1, CTLA-4, and LAG-3 showed an increasing trend, it remained low, suggesting minimal exhaustion (Figure S11I).

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