Heterogeneity characterization and key pathogenic genes screening based on diabetic nephropathy microenvironment.

Among the 15 key genes identified, ABCC9 was selected as the target gene for in-depth functional validation based on the following three considerations: First, ABCC9 demonstrates highly significant expression differences across distinct microenvironment subtypes and strongly correlates with the PCA score representing heterogeneity, indicating its close association with phenotypic variation.

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