Conversely, down-regulated genes exhibited a coordinated suppression of ECM components, supported by highly significant terms for ECM organization (R-HSA-1474244; ER = 3.25, FDR = 1 × 10 −5 ) and collagen chain trimerization (R-HSA-8948216; ER = 8.57, FDR = 1 × 10 −5 ).
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Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.
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