By contrast, although an obvious trend was present in the osteoarthritis group, the three core genes did not demonstrate statistically significant differences ( Figure 11B ). 3.5 PPI network construction and prediction of miRNA target genes and transcription factors To further investigate the different biological mechanisms of RA compared with osteoarthritis, we selected RA as the disease group for comparison with the significant DEGs in the osteoarthritis group.
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Identification of diagnostic genes in rheumatoid arthritis using integrated bioinformatics, machine learning, and experimental validation.
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