Immune Microenvironment and Genetic Signatures of End-Stage Renal Disease and Their Association with Sepsis: Insights from Public Transcriptomic Data and a Multicenter Clinical Cohort.

Biomedicines · 2026 · PMC13113169 · PMID 42072426

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

The signatures for CD8+ central memory T cells, CD4+ T cells, Th1 cells, and Th2 cells all showed highly significant negative enrichment scores, indicating systematic downregulation of these T-cell gene signatures in advanced kidney disease and suggesting a state of T-cell lymphopenia or exhaustion. 3.4.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.