Admission NT-proBNP as a Prognostic Biomarker for Ventilator Weaning Failure: Implications for Tracheostomy Timing.

Notably, SOFA and APACHE II themselves did not reach independent significance in multivariable analysis ( p = 0.737 and p = 0.470, respectively), whereas NT-proBNP remained a highly significant predictor ( p < 0.001), suggesting that it captures a dimension of cardiopulmonary vulnerability not adequately reflected by general severity-of-illness scores alone.

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