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Astro-Versus Microglia-Enriched Transcriptomes from Aged <i>Atxn2</i>-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies.

Cells · 2026 · PMC13115098 · PMID 42041567

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a statistical trendno p-value reported
Thirdly, microgliosis markers Aif1 , Trem2 , Hexb , Sall1 , Olfml3 , Hexb , Fcrls , Spi1 , Cx3cr1 , the microglia homeostasis marker P2ry12 , and the mature microglia marker Tmem119 appeared unchanged, while the Trem2 -signaling partner Tyrobp exhibited a statistical trend towards upregulation (log2FC 0.02 in microglial fraction).

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