The AGE-RAGE signaling pathway in diabetic complications (FDR = 3.81 × 10 −11 ) emerged as a highly significant shared node, while additional pathways related to metabolic disorders—including insulin resistance (FDR = 5.03 × 10 −7 ), sphingolipid signaling (FDR = 4.86 × 10 −8 ), and diabetic cardiomyopathy (FDR = 6.11 × 10 −11 )—were also enriched.
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Network Toxicology Reveals the Mechanisms of the Plasticizer Metabolite MECPP in Metabolic Diseases.
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