Space-Time Analysis of Burgeoning US Atrial Septal Defect Rates Driven by Cannabis.

J Xenobiot · 2026 · PMC13117238 · PMID 42041866

Europe PMC DOI

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highly significantp -values < 10 −15actually significant

In sophisticated geospatial regression models, cannabis exposure was highly significant, with p -values < 10 −15 both as a main effect and in interaction with tobacco and opioids and in a three-way interaction with tobacco and opioids together.

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