highly significantp < 0.0001
The model is expressed by the following equation: Y = 30.166 + 1.04125A − 1.26875B − 0.24C − 1.55AB − 0.2075AC + 0.4575BC − 2.168A 2 − 4.998B 2 − 2.7405C 2 Analysis of variance (ANOVA) revealed that the quadratic model was highly significant (F-value = 675.07, p < 0.0001; Table 8 ).