Intravenous administration of walnut leaf extract attenuates oxidative stress and improves insulin sensitivity and adipose tissue metabolism in feed-restricted fat-tailed ewes.

Statistical analysis confirmed highly significant effects of time (P < 0.001) and a significant time × treatment interaction on the glucose concentration curve throughout the ivGTT period (P < 0.001).

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Across the 9-day period, NEFA displayed an increasing trend in all animals due to negative energy balance, but the rise was consistently attenuated in WLE-treated ewes.

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Plasma glucose concentrations showed a decreasing trend during the experimental period.

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