The bladder cancer m<sup>6</sup>A landscape is defined by global methylation dilution and focal 3'-UTR hypermethylation.

The link between VIRMA amplification and overexpression was further supported by a correlation analysis of VIRMA copy number values and mRNA expression levels, which demonstrated a highly significant ( p = 3.02e-60, Pearson correlation) positive association (Fig. 5I ).

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