Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics.

J Transl Med · 2026 · PMC13122952 · PMID 42001187

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

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highly significantp < 0.0001actually significant

Conversely, MAPK10, linked to sigmoid colon tissue, exhibited exceptional accuracy in distinguishing tumor from normal samples, with AUC values of 0.9538 (COAD) and 0.9754 (READ), both highly significant ( p < 0.0001).

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