Impact of dose-adjusted tacrolimus exposure phenotype on outcomes in kidney transplantation: a large-scale multicenter cohort study.

Nevertheless, the borderline significance of the adjusted malignancy risk (P = 0.056) suggested an emerging safety signal that would become more apparent during longer follow-up periods. 3.5 Secondary outcomes (2–6 years) Among 5,505 patients followed beyond 1 year (4,250 fast-exposure and 1,255 slow-exposure phenotypes), significant differences emerged in safety outcomes, while efficacy remained comparable ( Table 5 ).

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