Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC).

Further filtering identified 18 phosphosites mapping to four distinct genes that exhibited highly significant differences ( p < 0.001) between tumor and non-tumor groups.

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While a slight trend toward improved survival probability in females was noted, it did not reach statistical significance 3.3.

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