Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury.

The SPT revealed a significant decrease in sucrose preference in the VEC-TBI group compared to the VEC-SHAM group, whereas the TRPC1-TBI group displayed an increasing trend in sucrose preference relative to the VEC-TBI group ( Figure 4G ).

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Western blot analysis revealed that the expression levels of synaptic proteins NR2A and NR2B were significantly decreased in the hippocampus of TBI mice compared to SHAM controls, while PSD95 expression showed a decreasing trend, suggesting synaptic damage in TBI-induced depressive mice ( Figures 1G – J ).

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