Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.

J Neurochem · 2026 · PMC13131041 · PMID 42059580

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a positive trendno p-value reported

However, an analysis of proliferating stem and progenitor cells (i.e., Ki67 + /Sox2 + and Ki67 + /DCX + cells, respectively) after 50 days of HTyr treatment revealed a significant increase in proliferation only in the ventral dentate gyrus, while the dorsal region exhibited a positive trend, which could explain the accumulation of neuroblasts and early postmitotic neurons (DCX + ) observed in both regions.

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