While there was a significant reduction in the complex viscosity (η*) of the mucus over time (as the model mucus breaks down naturally; visible particularly in the negative control), the effect of free NAC and the NAC-encapsulating NPs far outstripped this effect, being highly significant at both non-zero timepoints.
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Mucopenetrative Lipid-Polymer nanoparticles show Potent Anti-Inflammatory activity in a human Lung-on-Chip model.
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