Unbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests.

This led to the identification of additional elevated and highly significant markers: (a) alpha-1 antitrypsin, an acute phase reactant elevated during inflammatory conditions; (b) Interleukin 6 (IL-6), a pleiotropic cytokine associated with systemic inflammatory response syndrome 27 , shown to be elevated in severe COVID-19 28 and linked to endothelial damage and liver inju

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