Engineering L-Arg@ZIF-8 nanoparticles to modulate the immune-osteogenic-angiogenic microenvironment for accelerated bone fracture healing.

Discov Nano · 2026 · PMC13135582 · PMID 42068476

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The volcano plot visualized several highly significant differentially expressed genes, including key osteogenic markers such as Col1a1 , Col1a2 , and Sp7 , as well as critical regulators involved in bone remodeling and osteoclast differentiation, such as Mmp9, Acp5 (encoding TRAP), Tnfsf11 (RANKL), and Tnfrsf11a (RANK).

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