The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Hematol Transfus Cell Ther · 2026 · PMC13138160 · PMID 42048946

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highly significantp-value < 0.0001actually significant

Chi-square analysis demonstrated a highly significant deviation from Mendelian proportions (χ2 = 39.25; df = 2; p-value < 0.0001), indicating a marked underrepresentation of homozygous animals at birth.

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The murine Irs1 knockout model, generated by the spontaneous Irs1&lt;sup&gt;S57X&lt;/sup&gt; mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

The sentences

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.