Barely Significant
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Lymphocyte count and systemic immune-inflammation index (SII) as novel biomarkers for cognitive impairment: A cross-sectional study analysis.

Medicine (Baltimore) · 2026 · PMC13138424 · PMID 42065191

Europe PMCDOI
1
hedged sentence
0.0540
closest p · 1.1× alpha
0.0540
boldest claim

The sentences

borderline significantP = .054so close (0.05 < p ≤ 0.1)
The systemic immune-inflammation index emerged as a significant risk factor (OR: 1.008, 95% CI: 1.003–1.012, P = .002), indicating that each unit increase in SII was associated with a 1.008% increase in cognitive impairment risk.Among the evaluated inflammatory indices, the lymphocyte-to-monocyte ratio (LMR) exhibited a borderline significant association with cognitive impairment (OR: 0.651, 95% CI: 0.421–1.008, P = .054), suggesting a potential, albeit nonsignificant, protective trend (Table 4 ). 3.4.

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