We further used Jensen-Shannon divergence (JSD) scores to identify differentially deviated TF motifs across pseudotime between control and Tcf21 -KO ChromVar distributions, finding significant differences in many core TF motifs including Zeb, Klf, Runx1/2, AP-1, Srf, and Ctcf, while Tcf21 was borderline significant (padj = 0.10) (Fig. 5B ).
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Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk.
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