highly significantP = 2.44e-81
Remarkably, we observed a highly significant overlap (hypergeometric test, P = 2.44e-81) between the AS genes in smad1 -cKO (121/512) and smad1 -KD (121/660) PGCs (Fig. 7b ), such as ccdc187 (coiled-coil domain containing 187) that is involved in microtubule anchoring and located in the centrosome 51 , mak ( male germ cell associated kinase ) that encodes a serine/threonine protein kinase related to cell cycle regulation 52 , tinf2 ( TERF1-interacting nuclear factor 2 0) that encodes one subunit of shelterin complex involved in distinguishing between telomeres and DNA damage 53 , among others (Supplementary Fig. 7a ).