The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta-Analysis.

Pharmacol Res Perspect · 2026 · PMC13140511 · PMID 41814443

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hedged sentence

1.0000

closest p · 20.0× alpha

1.0000

boldest claim

The sentences

borderline significantp ≤ 1.0not close (p > 0.1)

Notably, the contour funnel plot revealed a borderline significant change in the muscle mass in the patients who received an SGLT2 inhibitor in five studies (0.1 < p ≤ 1.0), whereas significant reductions were observed in two studies (0.05 < p ≤ 0.1 and 0.01 < p ≤ 0.05, respectively) (Figure 3b ).

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