CRLF2 rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: a possible link?

Blood Adv · 2026 · PMC13141513 · PMID 41707115

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a nonsignificant trendno p-value reported

10 , 11 Interestingly, in the E1910 cohort of adults with newly diagnosed BCR-ABL–negative B-ALL, 8 the overall incidence of EMD was substantial, with a nonsignificant trend toward higher incidence of EMD in patients with CRLF2r , particularly in the CNS.

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