The non-monotonic dose-effect of resveratrol on testicular steroidogenesis in male arctic foxes (Vulpes lagopus): Mechanisms revealed by integrated transcriptomic and metabolomic analyses.

In this study, CYP19A1 expression showed a decreasing trend (non-significant) ( Table 2 ), whereas estrone levels showed an increasing trend (non-significant) ( Table 3 ), which may be associated with androstenedione accumulation.

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The total number of differential metabolites showed an increasing trend with higher doses. 3.4 Integrated analysis of transcriptomic and metabolomic data between GDZZ and GM2 A KEGG pathway co-enrichment analysis was performed on the GDZZ and GM2 groups ( Fig. 5 ). 11 key pathways were identified, whose functions can be primarily categorized into four aspects: steroid

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