hTERT-immortalized mesenchymal stem cell-derived EV treatment reduces ZIKV-induced cortical neuronal death, infection, and exosome-mediated transmission.

An increasing trend was noted in the uninfected group of neurons treated with hTERT-MSC-EV, but no significant differences were noted in comparison to the untreated and uninfected controls ( Fig.

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At 150 h, and in all tested groups (uninfected or ZIKV-infected and MSC-EVs-treated or untreated), we observed a decreasing trend in the expression of bax and caspases 3/9 compared to the gene expression noted at 96 h.

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