Antiviral effect of lactoferrin against infectious bronchitis virus (IBV) are associated with alterations in the gastrointestinal microbiome.

Highly significant differences ( p < 0.0001) were observed between the negative control and the IBV TW-II-infected group, and between the IBV TW-II-infected group and the groups treated with 50 mg/ml LF ( Fig. 12 B).

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Increasing trends in butyrate-producing genes were also observed following LF treatment, although these changes reached only marginal significance ( Fig. 7 ).

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