RT-qPCR analysis revealed an overall trend toward upregulation of BAP1 , ASXL2 , and ASXL3 mRNA in EO-PE samples, with the increase in ASXL2 reaching statistical significance, whereas ASXL1 levels remained unaltered (Fig. 1A and Supplementary Fig. 1A ).
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BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia.
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