highly significantP value = 9.06 × 10 −239
EV4A,B ; Dataset EV8 ) and found a highly significant overlap (OR = 5.72, P value = 9.06 × 10 −239 using all significant genes by JSD magnitude; OR = 14.98, P value = 3.43 × 10 −200 using top 1000 ranked by JSD magnitude for both) between differentially methylated genes identified by JSD in the isolated epidermis and whole skin during aging, supporting the validity of the original data in whole dorsal skin.