Polygenic risk modulates myocardial repolarization and T-wave geometry in congenital long-QT syndrome type 1: evidence from digital ECG phenotyping.

Following a 10-fold cross-validation Lasso regularization and step-wise refinement of parameters in the regression model, the overall explanatory power of the resulting model, as shown in Figure 1 : PRS ∼ 1 + QTcB + TPEcR + TWAcR * TWDcR, was modest with R 2 = 0.09, and model fit was highly significant (F-stat = 5.5, p = 0.00008).

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