A Perturb-seq map of a differentiation hub reveals synergistic vulnerabilities in KMT2A-rearranged acute myeloid leukemia.

Leukemia · 2026 · PMC13149302 · PMID 41882099

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The primary Gene Set Enrichment Analysis (GSEA) plot demonstrated a robust and highly significant positive enrichment for the Myeloid Program gene set when comparing the combination treatment to the control (NES = 1.77, p -adj = 2.13e−08) (Fig. 4E ).

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