Apigenin combined with aerobic exercise alleviates oxidative stress and inflammation in high-fat diet-induced NAFLD mice by modulating the Keap1/Nrf2/ARE pathway.

Sci Rep · 2026 · PMC13149865 · PMID 41865215

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4 and 5).The SOD and CAT enzyme activities in the liver tissues of the HFD group and the SO group significantly decreased when compared to the CON group; the activities in the HFD + API group and the HFD + AE group significantly increased when compared to the HFD group, with the HFD + API + AE group exhibiting the most significant increase with a highly significant difference.

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